Accutane is a powerful drug used in the treatment of acne. Four to five months of isotretinoin treatment usually leads to clearing of acne for one year or more after the medicine is stopped. Most other acne-controlling medicines are antibacterial agents, which are effective only if the medicine is used daily.Isotretinoin has significant side effects: (percentages are the ratio of people who received the side-effect) Chapped lips 90% , dry skin and itching 80% – the use of daily alpha hydroxacids will help prevent this side effect. Dryness of nose, mild nosebleed 80%, Irritation of the eyelids and eyes 40% – Vitamin E 400 IU each day may lessen this side effect. Joint and muscle pains 15%, Temporary hair thinning 10%, Rash 7%, Intestinal symptoms 5%, Urinary symptoms 5%, Headache 5%, Increased sensitivity to sunburn 5%, Decreased night vision <1%, Depression, thoughts of suicide <1% Isotretinoin may increase the level of blood fats, sometimes to risky levels. Occasionally it may affect the liver. That’s why regular blood tests are necessary when you are taking isotretinoin; these tests must be done when you have fasted for 12 hours (no breakfast), so that the blood fat determinations are reliable. A baseline blood chemistry test is established before patients start isotretinoin.